No pharmacokinetic interactions between candesartan and amlodipine following multiple oral administrations in healthy subjects
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No clinically significant pharmacokinetic interactions between dolutegravir and daclatasvir in healthy adult subjects
BACKGROUND Daclatasvir (DCV) is an NS5A replication complex inhibitor recently approved for chronic hepatitis C virus treatment. METHODS To assess drug interactions between the HIV integrase strand transfer inhibitor dolutegravir (DTG) and DCV, subjects were randomized into 1 of 2 sequences in an open-label, 3-period, crossover study. Subjects received either DTG 50 mg once daily or DCV 60 mg...
متن کاملNo Pharmacokinetic Drug–Drug Interaction Between Prasugrel and Vorapaxar Following Multiple‐Dose Administration in Healthy Volunteers
Vorapaxar is a first-in-class antagonist of the protease-activated receptor-1, the primary thrombin receptor on human platelets, which mediates the downstream effects of thrombin in hemostasis and thrombosis. Prasugrel is a platelet inhibitor that acts as a P2Y12 receptor antagonist through an active metabolite, R-138727. This study investigated the interaction of these 2 platelet antagonists w...
متن کاملFlorfenicol pharmacokinetics following intravenous and oral administrations and its elimination after oral and bath administrations in common carp (Cyprinus carpio)
The aim of this study was to evaluate pharmacokinetic profiles of florfenicol after a single dose of intravenous (5.00 mg kg-1 body weight) and oral (40.00 mg kg-1 body weight) administrations in common carp (Cyprinus carpio). The residue depletion of florfenicol was also investigated after oral administration (10.00 mg kg-1 body weight) and bath treatm...
متن کاملAbsence of Pharmacokinetic and Pharmacodynamic Interactions between Almorexant and Warfarin in Healthy Subjects
BACKGROUND AND OBJECTIVE Almorexant is the first representative of the new class of orexin receptor antagonists, which could become a new treatment option for insomnia. The present study investigated the potential interaction between almorexant and warfarin. METHODS In this open-label, two-way crossover, drug-drug interaction study, healthy male subjects received, in a randomized fashion, alm...
متن کاملChloroquine Phosphate Metabolism and Gender-Based Phenotypic Analysis among Healthy Subjects’ Urine Following Oral Administration
The advent of chloroquine promising activity against the COVID-19 is novel and as such, it is imperative to thoroughly understand and determine the rate at which individual body systems handle the drug. Chloroquine a known antimalarial drug belongs to the chemical class of 4-aminoquinolines. The aim of the study was to analyze Chloroquine and its metabolite in biological fluids of healthy subje...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2018
ISSN: 1177-8881
DOI: 10.2147/dddt.s172568